How different are humans from each other genetically ? How do scientists use these differences to trace historical human migrations? You will learn how to design an assay to detect DNA differences. Working in small teams, you will analyze some "mock" but realistic DNA samples from various regions. Together we will discuss what they tell us about human migration. We will present to you data gathered by scientists about human variation and migration. We will explain some concepts about how variations arise and are maintained and illustrate with examples of human traits: sickle cell anemia, malaria resistance, lactose intolerance, skin color. We will touch upon ethical issues regarding collecting DNA samples and the availability of genetic information.