ESP Biography



EDWIN CHANG, Scientist in Radiology and MIPS at Stanford




Major: Radiology

College/Employer: Stanford

Year of Graduation: Not available.

Picture of Edwin Chang

Brief Biographical Sketch:

I am a Basic Life Science Research Associate in the laboratory of Dr. Sam Gambhir. I also do collaborative projects with several post-doctoral fellows from the laboratories of Dr. Zhen Cheng and Dr. Rahim Beygui. I obtained my PhD from the Department of Medicine, Division of Experimental Medicine at McGill University where I studied the molecular pathophysiology of cardiovascular diseases. For my post-doctoral studies, I examined the impact of aging on cardiovascular function. I continued such research on vascular aging at the biotechnology company, Geron Corporation where I made a number of insights into the role of telomeres in tracking vascular aging, into the development of various non-radioactive bioassays to telomeres, and into the characterization of the RNA- and protein-components to telomerase. At Stanford, I studied the role of physiological state (hypoxia, inflammation), cytokines (e.g.VEGF, SDF-1α) and other molecules (nicotine, acetylcholinesterase inhibitors) on modulating the activation and mobilization of adult-derived stem cells (endothelial, hematopoietic and adipocytic) and the subsequent impact on vascular function. Recently, I have employed a number of radio-tracers (developed at Stanford) to follow neovascularization in growing tumors. I have leveraged these basic investigations into examining the appropriateness of non-invasive imaging techniques as therapy monitoring strategies to track the effectiveness of known and experimental anti-cancer drugs. I have also extended therapy monitoring and imaging strategies to look at novel treatments to glioblastomas. Chief among those treatments are interventions with Withaferin A, a lactonal steroid derived from the Winter Cherry tree or with alternating electric fields (tumor treating fields or TTF) or a combination of both.



Past Classes

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